@article {3136430,
	title = {Genomic instability in fragile sites-still adding the pieces},
	journal = {Genes Chromosomes Cancer},
	volume = {58},
	year = {2019},
	month = {2019 May},
	pages = {295-304},
	abstract = {Common fragile sites (CFSs) are specific genomic regions in normal chromosomes that exhibit genomic instability under DNA replication stress. As replication stress is an early feature of cancer development, CFSs are involved in the signature of genomic instability found in malignant tumors. The landscape of CFSs is tissue-specific and differs under different replication stress inducers. Nevertheless, the features underlying CFS sensitivity to replication stress are shared. Here, we review the events generating replication stress and discuss the unique characteristics of CFS regions and the cellular responses aimed to stabilizing these regions.},
	keywords = {Animals, Chromosome Fragile Sites, DNA, DNA Replication, Genomic Instability, Humans},
	issn = {1098-2264},
	doi = {10.1002/gcc.22715},
	url = { https://doi.org/10.1002/gcc.22715},
	author = {Irony-Tur Sinai, Michal and Kerem, Batsheva}
}
