The Batsheva Kerem group is focusing on Cancer Research and Personalized medicine approaches for Cystic Fibrosis.
Cancer Research
Genomic instability is a major driving force of tumorigenesis. Our goal is to understand the mechanisms underlying genomic instability during cancer development, with a focus on the role of oncogene and tumor suppressor-affected networks, in DNA replication stress, transcription and chromatin remodeling.
Personalized medicine approaches for Cystic Fibrosis
Cystic Fibrosis (CF) is the most prevalent lethal genetic disease in Caucasians caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Most of the CF-causing mutations are rare, causing a variety of clinical manifestation and disease severity. The field of rare disease management faces multiple challenges due to limited studies and data. Using patient-derived organoids we aim to develop therapeutic approaches for CF patients carrying rare mutations.